articles details

1）Dosage Form Characteristics:
The nasal spray leverages absorption across the nasal mucosa to bypass the blood–brain barrier, achieving high bioavailability and rapid central nervous system penetration. It is well suited for long-term management in mild to moderate cases.
2）Indications:
• Autism spectrum disorder (ASD)
• Amyotrophic lateral sclerosis (ALS)
• Post-stroke rehabilitation
• Alzheimer’s disease (AD) and other neurodegenerative disorders
3）Key Advantages:
• Convenience: Needle-free, self-administrable by patients.
• Central Targeting: Intranasal route enhances and accelerates CNS delivery.
• Chronic Disease Management: Supports maintenance therapy to improve patient quality of life.
• Reduced Systemic Burden: Localized nasal delivery minimizes hepatic and renal exposure.

‍